197282

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4464593..4465005 Replicon chromosome
Accession NZ_CP072054
Organism Escherichia coli strain K1508

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag J5N95_RS21460 Protein ID WP_000132601.1
Coordinates 4464593..4464934 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4464929..4465005 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5N95_RS21450 (4462006) 4462006..4463052 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
J5N95_RS21455 (4463052) 4463052..4464431 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
J5N95_RS21460 (4464593) 4464593..4464934 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4464929) 4464929..4465005 + 77 NuclAT_14 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_14 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_14 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_14 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_15 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_15 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_15 - Antitoxin
- (4464929) 4464929..4465005 + 77 NuclAT_15 - Antitoxin
J5N95_RS21465 (4465162) 4465162..4466556 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
J5N95_RS21470 (4466553) 4466553..4468142 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4457508..4466556 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T197282 WP_000132601.1 NZ_CP072054:c4464934-4464593 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T197282 NZ_CP095867:c2955259-2954870 [Acinetobacter nosocomialis]
TTGGTCAACCATTTGAATTTCAAACTGAAATATAGCCGTTTTGCGATTATATTTCAGTTTTTTATTGGCTTAAGTTTGGT
AGTTCTATTTTATCAACTCCTACCAATATTATGGTGGTTGGTTACGGTCAGTTTACTATTCATAAGTTTTATTTTCTTTT
TAAAGCGGCCACAGCTCGCTCAAATTGCTCATTTAGATCAAAAATTATGGTCACTTAGCTTTCATTCAGAACAAACAATT
TCTCGGGTAGAGATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTGAAGGGCATAAGACATTAACTTC
TGTTATTTGGTTTGATCAAATGCCTCTATCTCAGTGGAAACAACTTAAAACCTTAGAAAAATTTTATTAA

Antitoxin


Download         Length: 77 bp

>AT197282 NZ_CP072054:4464929-4465005 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References