Detailed information of TA system TA196720

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3601865..3602279
• Replicon: chromosome
• Accession: NZ_CP071693
• Organism: Salmonella sp. SAL-045

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: J1G49_RS17635
• Protein ID: WP_000994230.1
• Coordinates: 3602022..3602279 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3601865..3602197 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1G49_RS17595	3597126..3597623	-	498	WP_016695185.1	Saf-pilin pilus formation protein	-
J1G49_RS17600	3598386..3598956	-	571	Protein_3441	transposase family protein	-
J1G49_RS17605	3598877..3599086	-	210	WP_001676010.1	hypothetical protein	-
J1G49_RS17610	3599139..3599453	+	315	WP_072100769.1	type I toxin-antitoxin system SymE family toxin	-
J1G49_RS17615	3599520..3599798	-	279	WP_012543321.1	hypothetical protein	-
J1G49_RS17620	3600115..3600582	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
J1G49_RS17625	3600579..3600896	-	318	WP_001751277.1	hypothetical protein	-
J1G49_RS17630	3601454..3601687	-	234	WP_124084119.1	hypothetical protein	-
-	3601865..3602197	-	333	-	-	Antitoxin
J1G49_RS17635	3602022..3602279	+	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
J1G49_RS17640	3602345..3602791	-	447	WP_000171102.1	hypothetical protein	-
J1G49_RS17645	3602788..3605562	-	2775	WP_031622255.1	RHS domain-containing protein	-
J1G49_RS17650	3606027..3606668	-	642	WP_001676963.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3591557..3606084	14527
	-	flank	IS/Tn	-	-	3598386..3598664	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T196720 WP_000994230.1 NZ_CP071693:3602022-3602279 [Salmonella sp. SAL-045]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T196720 NZ_CP095271:c3739419-3739117 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT196720 NZ_CP071693:c3602197-3601865 [Salmonella sp. SAL-045]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin