Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4863259..4863861 Replicon chromosome
Accession NZ_CP071522
Organism Escherichia coli strain UPEC129

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag J3P56_RS23705 Protein ID WP_000897302.1
Coordinates 4863550..4863861 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J3P56_RS23700 Protein ID WP_000356397.1
Coordinates 4863259..4863549 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P56_RS23675 4859332..4860234 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
J3P56_RS23680 4860231..4860866 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
J3P56_RS23685 4860863..4861792 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
J3P56_RS23690 4862008..4862226 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
J3P56_RS23695 4862622..4862900 - 279 WP_001296612.1 hypothetical protein -
J3P56_RS23700 4863259..4863549 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
J3P56_RS23705 4863550..4863861 - 312 WP_000897302.1 hypothetical protein Toxin
J3P56_RS23710 4864098..4865318 - 1221 WP_000343765.1 ISL3-like element ISEc53 family transposase -
J3P56_RS23715 4865337..4865855 - 519 WP_000115885.1 ClbS/DfsB family four-helix bundle protein -
J3P56_RS23720 4865983..4866891 + 909 WP_001331553.1 alpha/beta hydrolase -
J3P56_RS23725 4866955..4867896 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
J3P56_RS23730 4867941..4868378 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4864098..4865318 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T196561 WP_000897302.1 NZ_CP071522:c4863861-4863550 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T196561 NZ_CP095161:2561193-2561483 [Avibacterium paragallinarum]
ATGACCTATAAACTTTCTTTTGATAAACGGGCGTTAAAAGAATGGCATAAATTGGGCGATACCCTACGCCAACAATTTAA
AGCAAAATTAATCGAACGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGCTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGGGTGATTGTGCTTTCAGTAGGCAAA
AGAGAACGCCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT196561 WP_000356397.1 NZ_CP071522:c4863549-4863259 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT196561 NZ_CP095161:2560943-2561203 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGACACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCCGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References