Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4863259..4863861 | Replicon | chromosome |
Accession | NZ_CP071522 | ||
Organism | Escherichia coli strain UPEC129 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | J3P56_RS23705 | Protein ID | WP_000897302.1 |
Coordinates | 4863550..4863861 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | J3P56_RS23700 | Protein ID | WP_000356397.1 |
Coordinates | 4863259..4863549 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J3P56_RS23675 | 4859332..4860234 | + | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
J3P56_RS23680 | 4860231..4860866 | + | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
J3P56_RS23685 | 4860863..4861792 | + | 930 | WP_000027720.1 | formate dehydrogenase accessory protein FdhE | - |
J3P56_RS23690 | 4862008..4862226 | - | 219 | WP_001314326.1 | ribbon-helix-helix domain-containing protein | - |
J3P56_RS23695 | 4862622..4862900 | - | 279 | WP_001296612.1 | hypothetical protein | - |
J3P56_RS23700 | 4863259..4863549 | - | 291 | WP_000356397.1 | helix-turn-helix domain-containing protein | Antitoxin |
J3P56_RS23705 | 4863550..4863861 | - | 312 | WP_000897302.1 | hypothetical protein | Toxin |
J3P56_RS23710 | 4864098..4865318 | - | 1221 | WP_000343765.1 | ISL3-like element ISEc53 family transposase | - |
J3P56_RS23715 | 4865337..4865855 | - | 519 | WP_000115885.1 | ClbS/DfsB family four-helix bundle protein | - |
J3P56_RS23720 | 4865983..4866891 | + | 909 | WP_001331553.1 | alpha/beta hydrolase | - |
J3P56_RS23725 | 4866955..4867896 | - | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
J3P56_RS23730 | 4867941..4868378 | - | 438 | WP_000560983.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 4864098..4865318 | 1220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T196561 WP_000897302.1 NZ_CP071522:c4863861-4863550 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T196561 NZ_CP095161:2561193-2561483 [Avibacterium paragallinarum]
ATGACCTATAAACTTTCTTTTGATAAACGGGCGTTAAAAGAATGGCATAAATTGGGCGATACCCTACGCCAACAATTTAA
AGCAAAATTAATCGAACGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGCTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGGGTGATTGTGCTTTCAGTAGGCAAA
AGAGAACGCCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA
ATGACCTATAAACTTTCTTTTGATAAACGGGCGTTAAAAGAATGGCATAAATTGGGCGATACCCTACGCCAACAATTTAA
AGCAAAATTAATCGAACGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGCTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGGGTGATTGTGCTTTCAGTAGGCAAA
AGAGAACGCCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT196561 WP_000356397.1 NZ_CP071522:c4863549-4863259 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT196561 NZ_CP095161:2560943-2561203 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGACACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCCGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA
ATGGCAATTCAGCAAATTTTAACCCGACACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCCGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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