196541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2409829..2411417 Replicon chromosome
Accession NZ_CP071522
Organism Escherichia coli strain UPEC129

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag J3P56_RS11610 Protein ID WP_001125475.1
Coordinates 2409829..2411151 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J3P56_RS11615 Protein ID WP_001332145.1
Coordinates 2411151..2411417 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3P56_RS11590 2406978..2407688 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
J3P56_RS11595 2408050..2408334 - 285 Protein_2269 fimbrial protein -
J3P56_RS11600 2408910..2409293 - 384 Protein_2270 NAD(P)H-binding protein -
J3P56_RS11605 2409313..2409570 + 258 WP_001210030.1 hypothetical protein -
J3P56_RS11610 2409829..2411151 - 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
J3P56_RS11615 2411151..2411417 - 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
J3P56_RS11620 2411725..2412483 + 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
J3P56_RS11625 2412487..2413401 - 915 WP_001306069.1 bestrophin family protein -
J3P56_RS11630 2413598..2415049 - 1452 WP_113454535.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimA 2396268..2411417 15149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T196541 WP_001125475.1 NZ_CP071522:c2411151-2409829 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T196541 NZ_CP095155:2789468-2789575 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT196541 WP_001332145.1 NZ_CP071522:c2411417-2411151 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT196541 NZ_CP095155:c2789421-2789355 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References