Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1167049..1168550 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name tglT Uniprot ID -
Locus tag JZL63_RS05480 Protein ID WP_206280998.1
Coordinates 1167669..1168550 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag JZL63_RS05475 Protein ID WP_003405517.1
Coordinates 1167049..1167672 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS05455 1162545..1163372 - 828 WP_206280997.1 PE domain-containing protein -
JZL63_RS05460 1164160..1164399 - 240 WP_096871986.1 hypothetical protein -
JZL63_RS05465 1164568..1165495 - 928 Protein_1076 IS5-like element ISMt1 family transposase -
JZL63_RS05470 1165777..1166802 - 1026 WP_003405514.1 serine protease -
JZL63_RS05475 1167049..1167672 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JZL63_RS05480 1167669..1168550 + 882 WP_206280998.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JZL63_RS05485 1169419..1170666 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
JZL63_RS05490 1171034..1172149 - 1116 WP_206280999.1 hypothetical protein -
JZL63_RS05495 1172106..1172309 - 204 WP_003405585.1 hypothetical protein -
JZL63_RS05500 1172382..1172828 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1158914..1170666 11752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31988.67 Da        Isoelectric Point: 6.3901

>T195409 WP_206280998.1 NZ_CP071128:1167669-1168550 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTTPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T195409 NZ_CP094713:996523-996675 [Staphylococcus schleiferi]
ATGAAAGATGATCAAAAACAATATGAAAATGAAATGGTCGAAGGTTTTGATGATGTCGTTGAATTAGGCAAAGAGATGGA
ACAAATTTCAGAAAAAAATGATCAAGATAAATTAAATCAAGATCATGATGCTGATATTCGATCAGATAAGTAA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT195409 WP_003405517.1 NZ_CP071128:1167049-1167672 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT195409 NZ_CP094713:995905-996504 [Staphylococcus schleiferi]
ATGGCAATGAATTTTAAAATATTTAAAGATGCAGAAACAGTGGCAAAATATACAGCAGATATCTTAAGAAAACAGCTTAA
TAATAATCCTACCTCAATTGTAGGTGTCCATTTAAATGAAGACCAAGCGCCGGTTTTAAATTTTTTAAAACAAGATGTTG
ATCGTCATAGTGTAGATTTTAGTCAAATTCATATTTTGGACTATGATAAGCAAGCGTCATTTTTTAAATCATTAGGCGTA
CCAGAGAAACAAGTGCATGAAGTTCCAGATGATGACAATGTTGAATCATTTATTGCCCATCATGCTAAAACAAAAGATAA
CAAAGGAAAATTAACGTTACAAGTATTAACTATTGATGAAAACGGACAAATTGGGTTACCAATGAATGATGCCGTAATGC
CAGCGCGTGAAATTATTGTCGTTGTCACAGGTTCAAATAAAGCGGCACAAGTTCAAAAGTTATATGAAGAAAATGGGAAT
ACAAGCTTTATTCCGTCAACATTAAAAACACATCGTATGGTGACTGTTGTCCTTGATGAAGCGGCTGCACAAGGTTTACC
AGATGATGTTAGAGCCTATTTTACTTCATTATATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References