Detailed information of TA system TA195348

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): TglT-TakA/AbiEii-AbiEi
• Location: 1167049..1168550
• Replicon: chromosome
• Accession: NZ_CP071127
• Organism: Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)

• Gene name: tglT
• Uniprot ID: -
• Locus tag: JY387_RS05485
• Protein ID: WP_206338145.1
• Coordinates: 1167669..1168550 (+)
• Length: 294 a.a.

Antitoxin (Protein)

• Gene name: takA
• Uniprot ID: L7N5C7
• Locus tag: JY387_RS05480
• Protein ID: WP_003405517.1
• Coordinates: 1167049..1167672 (+)
• Length: 208 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY387_RS05460	1162545..1163372	-	828	WP_206280997.1	PE domain-containing protein	-
JY387_RS05465	1164160..1164399	-	240	WP_096871986.1	hypothetical protein	-
JY387_RS05470	1164568..1165495	-	928	Protein_1077	IS5-like element ISMt1 family transposase	-
JY387_RS05475	1165777..1166802	-	1026	WP_003405514.1	serine protease	-
JY387_RS05480	1167049..1167672	+	624	WP_003405517.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JY387_RS05485	1167669..1168550	+	882	WP_206338145.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JY387_RS05490	1169419..1170666	+	1248	WP_003901078.1	IS256-like element IS1081 family transposase	-
JY387_RS05495	1171034..1172149	-	1116	WP_206280999.1	hypothetical protein	-
JY387_RS05500	1172106..1172309	-	204	WP_003405585.1	hypothetical protein	-
JY387_RS05505	1172382..1172828	+	447	WP_003405595.1	oxidation-sensing regulator MosR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000962 Mycobacterium tuberculosis H37Rv IScluster/Tn TA010016 1158918..1170670 0.001	inside	IScluster/Tn	-	esxN	1158914..1170666	11752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (49-279)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (18-66)

Sequences

Toxin

Protein

• Length: 294 a.a.
• Molecular weight: 31988.67 Da
• Isoelectric Point: 6.3901

>T195348 WP_206338145.1 NZ_CP071127:1167669-1168550 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTTPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Nucleotide

• Length: 882 bp

>T195348 NZ_CP094624:3052427-3052777 [Bacillus thuringiensis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 208 a.a.
• Molecular weight: 22531.68 Da
• Isoelectric Point: 10.0518

>AT195348 WP_003405517.1 NZ_CP071127:1167049-1167672 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Nucleotide

• Length: 624 bp

>AT195348 NZ_CP094624:3052135-3052422 [Bacillus thuringiensis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BT71