Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 967815..967997 Replicon chromosome
Accession NZ_CP069470
Organism Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag I6J76_RS05120 Protein ID WP_001801861.1
Coordinates 967902..967997 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 967815..967874 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J76_RS05105 966953..967330 + 378 WP_001037045.1 DUF1433 domain-containing protein -
I6J76_RS05110 967524..967700 + 177 Protein_968 transposase -
I6J76_RS05115 967678..967779 - 102 WP_001791893.1 hypothetical protein -
- 967815..967874 + 60 - - Antitoxin
I6J76_RS05120 967902..967997 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
I6J76_RS05125 968200..968343 + 144 WP_001549059.1 transposase -
I6J76_RS05130 968947..969330 + 384 WP_000070811.1 hypothetical protein -
I6J76_RS05135 969341..969517 + 177 WP_000375476.1 hypothetical protein -
I6J76_RS05140 969519..969704 + 186 WP_000809857.1 hypothetical protein -
I6J76_RS05145 969818..970459 + 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
I6J76_RS05150 970677..971228 - 552 WP_000414205.1 hypothetical protein -
I6J76_RS05155 971326..971670 - 345 WP_000627551.1 DUF3969 family protein -
I6J76_RS05160 971711..972337 - 627 Protein_978 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlgA / lukD 934726..974897 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T190575 WP_001801861.1 NZ_CP069470:c967997-967902 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T190575 NZ_CP091465:c1274075-1273686 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 60 bp

>AT190575 NZ_CP069470:967815-967874 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References