Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
Location | 967815..967997 | Replicon | chromosome |
Accession | NZ_CP069470 | ||
Organism | Staphylococcus aureus strain FDAARGOS_1246 |
Toxin (Protein)
Gene name | sprA1 | Uniprot ID | - |
Locus tag | I6J76_RS05120 | Protein ID | WP_001801861.1 |
Coordinates | 967902..967997 (-) | Length | 32 a.a. |
Antitoxin (RNA)
Gene name | sprA1AS | ||
Locus tag | - | ||
Coordinates | 967815..967874 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J76_RS05105 | 966953..967330 | + | 378 | WP_001037045.1 | DUF1433 domain-containing protein | - |
I6J76_RS05110 | 967524..967700 | + | 177 | Protein_968 | transposase | - |
I6J76_RS05115 | 967678..967779 | - | 102 | WP_001791893.1 | hypothetical protein | - |
- | 967815..967874 | + | 60 | - | - | Antitoxin |
I6J76_RS05120 | 967902..967997 | - | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
I6J76_RS05125 | 968200..968343 | + | 144 | WP_001549059.1 | transposase | - |
I6J76_RS05130 | 968947..969330 | + | 384 | WP_000070811.1 | hypothetical protein | - |
I6J76_RS05135 | 969341..969517 | + | 177 | WP_000375476.1 | hypothetical protein | - |
I6J76_RS05140 | 969519..969704 | + | 186 | WP_000809857.1 | hypothetical protein | - |
I6J76_RS05145 | 969818..970459 | + | 642 | WP_000494956.1 | ImmA/IrrE family metallo-endopeptidase | - |
I6J76_RS05150 | 970677..971228 | - | 552 | WP_000414205.1 | hypothetical protein | - |
I6J76_RS05155 | 971326..971670 | - | 345 | WP_000627551.1 | DUF3969 family protein | - |
I6J76_RS05160 | 971711..972337 | - | 627 | Protein_978 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | hlgA / lukD | 934726..974897 | 40171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T190575 WP_001801861.1 NZ_CP069470:c967997-967902 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T190575 NZ_CP091465:c1274075-1273686 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 60 bp
>AT190575 NZ_CP069470:967815-967874 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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