190318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 3208287..3208699 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag JSW75_RS15415 Protein ID WP_000132601.1
Coordinates 3208287..3208628 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 3208623..3208699 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS15405 (3205700) 3205700..3206746 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
JSW75_RS15410 (3206746) 3206746..3208125 - 1380 WP_072647343.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
JSW75_RS15415 (3208287) 3208287..3208628 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (3208623) 3208623..3208699 + 77 NuclAT_14 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_14 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_14 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_14 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_15 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_15 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_15 - Antitoxin
- (3208623) 3208623..3208699 + 77 NuclAT_15 - Antitoxin
JSW75_RS15420 (3208856) 3208856..3210250 - 1395 WP_072647344.1 type I restriction-modification system specificity subunit -
JSW75_RS15425 (3210247) 3210247..3211836 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3201202..3210250 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T190318 WP_000132601.1 NZ_CP069386:c3208628-3208287 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T190318 NZ_CP091244:c31679-31422 [Thiothrix winogradskyi]
ATGCGAATAATCTTTTCATCCAAAGCGTGGGAGGATTATGTGCATTGGCAACAAGCCGACAAGAAAATACTCAAGCGTAT
CAATGATCTGATCAAAGCGATTTCGCGTGATCCGTTTGACGGTATCGGCAAGCCCGAACCGTTGCGGCACGGGCTTTCTG
GCTATTGGTCACGCCGTATCAATGATGAACATCGGTTGGTCTACAAATTGGAAGGCGAGGACTTGCTGATAGCGATGTGT
CGGTATCACTATCAATAA

Antitoxin


Download         Length: 77 bp

>AT190318 NZ_CP069386:3208623-3208699 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References