Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1164464..1165965 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag JN136_RS05555 Protein ID WP_003898703.1
Coordinates 1165084..1165965 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag JN136_RS05550 Protein ID WP_003405517.1
Coordinates 1164464..1165087 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS05530 1159961..1160788 - 828 WP_003405370.1 PE domain-containing protein -
JN136_RS05535 1161576..1161815 - 240 WP_003405375.1 hypothetical protein -
JN136_RS05540 1161984..1162910 - 927 WP_078386733.1 IS5 family transposase -
JN136_RS05545 1163192..1164217 - 1026 WP_003405514.1 serine protease -
JN136_RS05550 1164464..1165087 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN136_RS05555 1165084..1165965 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN136_RS05560 1166432..1167693 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
JN136_RS05565 1168193..1169440 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
JN136_RS05570 1169808..1170923 - 1116 WP_003405582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1156330..1169440 13110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T189722 WP_003898703.1 NZ_CP069076:1165084-1165965 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T189722 NZ_CP090941:1993046-1993507 [Staphylococcus epidermidis]
GTGGGGAAATATGAGGATATGTTAATTGAACATGACTATATTGAAGTCATTGAATGTGATAACTTACCTAAAAGGTTATC
TGGCTTGTGGCTTGGAGATATGATTTTAATTAATCGTAACTTACCTATTACTTCCAAACTTGAAACACTTGCAGAGGAAC
TCGCTCATAACGAACTTACATATGGAAATATAGTTGATCAAAGTAGTTTTAATCATAGAAAATTTGAAGGTTATGCACGT
AGGTTAGCCTATGAAAAGTTAGTCCCTCTTAAAGATATTGTAAAAGCATTTTTGCAAGGCATTCATGACTTGTATGAACT
TGCAAATTTTTTTGAGGTTACAGAAGGTTTTGTCCAACAAAGTATTGCACATTATAAACAAAAATATGGCTTAACAACTC
GATGTGGTGATTATGTTATAGCATTTGAACCTTTAAGAGTTTTTGAGTACAAAGAAATATAG

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT189722 WP_003405517.1 NZ_CP069076:1164464-1165087 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT189722 NZ_CP090941:1992719-1993033 [Staphylococcus epidermidis]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATTAAAAATCTTAAAAATGATACTATTGAAAGTATAGCTACTG
CATTAAATGTTAACCCTGCTTTCTTGATGGGTTGGATAGAAGATGTTGAGGAACAACCACAACATCGTGCAGCACATCTT
GATGGTGATTTAACTGACGAAGAATGGCAAGAAATTCTTGATTACGCTGAATACATAAGAAGTAAAAGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References