Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1172240..1173741 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag JN139_RS05600 Protein ID WP_003898703.1
Coordinates 1172860..1173741 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag JN139_RS05595 Protein ID WP_003405517.1
Coordinates 1172240..1172863 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS05575 1167735..1168562 - 828 WP_003405370.1 PE domain-containing protein -
JN139_RS05580 1169350..1169589 - 240 WP_003405375.1 hypothetical protein -
JN139_RS05585 1169758..1170685 - 928 Protein_1098 IS5-like element ISMt1 family transposase -
JN139_RS05590 1170968..1171993 - 1026 WP_003405514.1 serine protease -
JN139_RS05595 1172240..1172863 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN139_RS05600 1172860..1173741 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN139_RS05605 1174611..1175858 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
JN139_RS05610 1176226..1177341 - 1116 WP_003405582.1 hypothetical protein -
JN139_RS05615 1177298..1177501 - 204 WP_003405585.1 hypothetical protein -
JN139_RS05620 1177574..1178020 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1164104..1175858 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T189601 WP_003898703.1 NZ_CP069074:1172860-1173741 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T189601 NZ_CP090885:1074396-1075154 [Streptococcus pneumoniae]
ATGGATATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTTCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAATATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAAGAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAATACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATTAACCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT189601 WP_003405517.1 NZ_CP069074:1172240-1172863 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT189601 NZ_CP090885:1073920-1074396 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACCCAACCCGAATTTGCACGGATTGTAGGTATTTC
ACGTAATAGTCTGAGTCGATATGAAAATGGAACGAGTTCAGTTTCTACGGAACTAATAGACATCATTTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTAACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCGAATCTATTATCTCGACTCTATCGTTATCAAGATAATCGGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATTTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References