Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1168370..1169871 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag JN142_RS05575 Protein ID WP_003898703.1
Coordinates 1168990..1169871 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID -
Locus tag JN142_RS05570 Protein ID WP_031697658.1
Coordinates 1168370..1168993 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS05550 1163865..1164692 - 828 WP_003405370.1 PE domain-containing protein -
JN142_RS05555 1165480..1165719 - 240 WP_009936438.1 hypothetical protein -
JN142_RS05560 1165888..1166815 - 928 Protein_1095 IS5-like element ISMt1 family transposase -
JN142_RS05565 1167098..1168123 - 1026 WP_003405514.1 serine protease -
JN142_RS05570 1168370..1168993 + 624 WP_031697658.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN142_RS05575 1168990..1169871 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN142_RS05580 1170741..1171988 + 1248 WP_003900260.1 IS256-like element IS1081 family transposase -
JN142_RS05585 1172356..1173471 - 1116 WP_003405582.1 hypothetical protein -
JN142_RS05590 1173428..1173631 - 204 WP_003405585.1 hypothetical protein -
JN142_RS05595 1173704..1174150 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1158876..1171988 13112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T189419 WP_003898703.1 NZ_CP069071:1168990-1169871 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T189419 NZ_CP090761:2245835-2246134 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCTCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGCCGCCAAGGCTGCCGCGTGA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22478.63 Da        Isoelectric Point: 9.5242

>AT189419 WP_031697658.1 NZ_CP069071:1168370-1168993 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLCARPKRASA

Download         Length: 624 bp

>AT189419 NZ_CP090761:2245493-2245831 [Burkholderia cenocepacia]
ATGGTTTACACATTGCAATGCATGCCCTACAGTCCTCCTGCATTCGGCATCCGGACCACCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCCCGATCGCCTCGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTGTGCGGCGGAGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GTACCTCGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure

References