Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1168487..1169988 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name tglT Uniprot ID -
Locus tag JN143_RS05575 Protein ID WP_057288560.1
Coordinates 1169107..1169988 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag JN143_RS05570 Protein ID WP_003405517.1
Coordinates 1168487..1169110 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS05550 1163982..1164809 - 828 WP_003405370.1 PE domain-containing protein -
JN143_RS05555 1165597..1165836 - 240 WP_009936438.1 hypothetical protein -
JN143_RS05560 1166005..1166932 - 928 Protein_1096 IS5-like element ISMt1 family transposase -
JN143_RS05565 1167215..1168240 - 1026 WP_003405514.1 serine protease -
JN143_RS05570 1168487..1169110 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
JN143_RS05575 1169107..1169988 + 882 WP_057288560.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN143_RS05580 1170858..1172105 + 1248 WP_003900260.1 IS256-like element IS1081 family transposase -
JN143_RS05585 1172473..1173588 - 1116 WP_003405582.1 hypothetical protein -
JN143_RS05590 1173545..1173748 - 204 WP_003405585.1 hypothetical protein -
JN143_RS05595 1173821..1174267 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1160351..1172105 11754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31984.68 Da        Isoelectric Point: 6.2444

>T189358 WP_057288560.1 NZ_CP069070:1169107-1169988 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIYEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T189358 NZ_CP090740:c3335622-3335221 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGGTCACCTATGCGGAGCTCGAGTACGGCGTGACGCTATGCGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT189358 WP_003405517.1 NZ_CP069070:1168487-1169110 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT189358 NZ_CP090740:c3335858-3335622 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCAGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References