Detailed information of TA system TA187295

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3650565..3650761
• Replicon: chromosome
• Accession: NZ_CP068561
• Organism: Clostridioides difficile strain CD9301

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW49_RS16490
• Protein ID: WP_003424190.1
• Coordinates: 3650565..3650717 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	3650661..3650761 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW49_RS16465	3645650..3646291	+	642	WP_003424198.1	SdpI family protein	-
JMW49_RS16470	3646551..3646882	+	332	Protein_3164	carboxymuconolactone decarboxylase family protein	-
JMW49_RS16475	3647414..3647578	+	165	WP_003424195.1	hypothetical protein	-
JMW49_RS16480	3647802..3648647	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW49_RS16485	3649192..3649737	-	546	WP_077699404.1	site-specific integrase	-
JMW49_RS16490	3650565..3650717	+	153	WP_003424190.1	hypothetical protein	Toxin
-	3650661..3650761	-	101	NuclAT_0	-	Antitoxin
JMW49_RS16495	3654641..3654829	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
JMW49_RS16500	3655017..3655250	+	234	WP_003424184.1	hypothetical protein	-
JMW49_RS16505	3655237..3655494	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3643655..3666791	23136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187295 WP_003424190.1 NZ_CP068561:3650565-3650717 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187295 NZ_CP089781:c752578-752141 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187295 NZ_CP068561:c3650761-3650661 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin