Detailed information of TA system TA187292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2989550..2989746
• Replicon: chromosome
• Accession: NZ_CP068560
• Organism: Clostridioides difficile strain CD9001

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW55_RS13460
• Protein ID: WP_003424190.1
• Coordinates: 2989550..2989702 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2989646..2989746 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW55_RS13430	2984635..2985276	+	642	WP_003424198.1	SdpI family protein	-
JMW55_RS13435	2985536..2985867	+	332	Protein_2560	carboxymuconolactone decarboxylase family protein	-
JMW55_RS13440	2986399..2986563	+	165	WP_003424195.1	hypothetical protein	-
JMW55_RS13445	2986787..2987632	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW55_RS13450	2988177..2988722	-	546	WP_077699404.1	site-specific integrase	-
JMW55_RS13455	2988788..2989030	-	243	WP_003424191.1	hypothetical protein	-
JMW55_RS13460	2989550..2989702	+	153	WP_003424190.1	hypothetical protein	Toxin
-	2989646..2989746	-	101	NuclAT_0	-	Antitoxin
JMW55_RS13465	2993626..2993814	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
JMW55_RS13470	2994002..2994235	+	234	WP_003424184.1	hypothetical protein	-
JMW55_RS13475	2994222..2994479	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187292 WP_003424190.1 NZ_CP068560:2989550-2989702 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187292 NZ_CP089781:714555-714962 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187292 NZ_CP068560:c2989746-2989646 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin