Detailed information of TA system TA187289

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1516499..1516695
• Replicon: chromosome
• Accession: NZ_CP068559
• Organism: Clostridioides difficile strain CD9701

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW50_RS06935
• Protein ID: WP_003424190.1
• Coordinates: 1516543..1516695 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1516499..1516599 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW50_RS06920	1511766..1512023	-	258	WP_003424182.1	hypothetical protein	-
JMW50_RS06925	1512010..1512243	-	234	WP_003424184.1	hypothetical protein	-
JMW50_RS06930	1512431..1512619	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
-	1516499..1516599	+	101	NuclAT_0	-	Antitoxin
JMW50_RS06935	1516543..1516695	-	153	WP_003424190.1	hypothetical protein	Toxin
JMW50_RS06940	1517215..1517457	+	243	WP_003424191.1	hypothetical protein	-
JMW50_RS06945	1517523..1518068	+	546	WP_077699404.1	site-specific integrase	-
JMW50_RS06950	1518613..1519458	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW50_RS06955	1519682..1519846	-	165	WP_003424195.1	hypothetical protein	-
JMW50_RS06960	1520378..1520709	-	332	Protein_1383	carboxymuconolactone decarboxylase family protein	-
JMW50_RS06965	1520969..1521610	-	642	WP_003424198.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1507894..1518068	10174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187289 WP_003424190.1 NZ_CP068559:c1516695-1516543 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187289 NZ_CP089781:699759-700160 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187289 NZ_CP068559:1516499-1516599 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin