Detailed information of TA system TA187279

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3040862..3041065
• Replicon: chromosome
• Accession: NZ_CP068558
• Organism: Clostridioides difficile strain CD9501

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: -
• Locus tag: JMW52_RS14765
• Protein ID: WP_237774986.1
• Coordinates: 3040877..3041065 (-)
• Length: 63 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	3040862..3040934 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW52_RS19995 (3035974)	3035974..3036108	-	135	WP_273542652.1	hypothetical protein	-
JMW52_RS14725 (3036689)	3036689..3036907	-	219	WP_009889000.1	hypothetical protein	-
JMW52_RS14730 (3036976)	3036976..3037404	-	429	WP_237774981.1	hypothetical protein	-
JMW52_RS14735 (3037434)	3037434..3037775	-	342	WP_237774982.1	ORF6N domain-containing protein	-
JMW52_RS20000 (3037882)	3037882..3037980	-	99	WP_273542653.1	BRO family protein	-
JMW52_RS20005 (3038001)	3038001..3038207	-	207	WP_273542654.1	BRO family protein	-
JMW52_RS14745 (3038221)	3038221..3038388	-	168	WP_022621726.1	hypothetical protein	-
JMW52_RS14750 (3038888)	3038888..3039199	+	312	WP_237774983.1	helix-turn-helix transcriptional regulator	-
JMW52_RS14755 (3039230)	3039230..3039385	-	156	WP_237774984.1	hypothetical protein	-
JMW52_RS14760 (3040166)	3040166..3040300	+	135	WP_237774985.1	helix-turn-helix transcriptional regulator	-
- (3040862)	3040862..3040934	+	73	NuclAT_6	-	Antitoxin
- (3040862)	3040862..3040934	+	73	NuclAT_6	-	Antitoxin
- (3040862)	3040862..3040934	+	73	NuclAT_8	-	Antitoxin
JMW52_RS14765 (3040877)	3040877..3041065	-	189	WP_237774986.1	hypothetical protein	Toxin
JMW52_RS14770 (3041214)	3041214..3042639	-	1426	Protein_2868	cell wall-binding repeat-containing protein	-
JMW52_RS14775 (3042877)	3042877..3043362	+	486	WP_237774988.1	NTF2-like N-terminal transpeptidase domain-containing protein	-
JMW52_RS14785 (3043539)	3043539..3043649	+	111	WP_235689130.1	tetratricopeptide repeat protein	-
JMW52_RS14790 (3043773)	3043773..3045287	+	1515	WP_003419256.1	recombinase family protein	-
JMW52_RS14795 (3045313)	3045313..3045597	+	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7093.30 Da
• Isoelectric Point: 9.8373

>T187279 WP_237774986.1 NZ_CP068558:c3041065-3040877 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKQKATLAQRVTYELNLNLYLNPKINSVYDELHSTAK

Nucleotide

• Length: 189 bp

>T187279 NZ_CP089780:3832377-3832787 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Nucleotide

• Length: 73 bp

>AT187279 NZ_CP068558:3040862-3040934 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCAGTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTGGATTTAAATAT

Structures

Antitoxin