Detailed information of TA system TA187277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3016845..3017041
• Replicon: chromosome
• Accession: NZ_CP068558
• Organism: Clostridioides difficile strain CD9501

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW52_RS14545
• Protein ID: WP_003424190.1
• Coordinates: 3016889..3017041 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	3016845..3016945 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW52_RS14500 (3011958)	3011958..3012056	-	99	WP_237774960.1	hypothetical protein	-
JMW52_RS14505 (3012074)	3012074..3012256	-	183	WP_237774961.1	hypothetical protein	-
JMW52_RS14510 (3012386)	3012386..3012559	-	174	WP_237774962.1	hypothetical protein	-
JMW52_RS14515 (3012735)	3012735..3013058	-	324	WP_237774963.1	hypothetical protein	-
JMW52_RS19985 (3013127)	3013127..3013258	-	132	WP_273542650.1	hypothetical protein	-
JMW52_RS14520 (3013844)	3013844..3014002	-	159	WP_237774964.1	hypothetical protein	-
JMW52_RS14525 (3014056)	3014056..3014922	-	867	WP_009894371.1	BRO family protein	-
JMW52_RS14530 (3015042)	3015042..3015230	-	189	WP_004454585.1	virulence factor Srl	-
JMW52_RS14535 (3015717)	3015717..3016082	+	366	WP_021365222.1	DUF2513 domain-containing protein	-
JMW52_RS14540 (3016085)	3016085..3016252	-	168	WP_237774965.1	hypothetical protein	-
- (3016845)	3016845..3016945	+	101	NuclAT_5	-	Antitoxin
- (3016845)	3016845..3016945	+	101	NuclAT_5	-	Antitoxin
- (3016845)	3016845..3016945	+	101	NuclAT_7	-	Antitoxin
JMW52_RS14545 (3016889)	3016889..3017041	-	153	WP_003424190.1	hypothetical protein	Toxin
JMW52_RS14550 (3017388)	3017388..3017786	-	399	Protein_2821	phage portal protein	-
JMW52_RS14555 (3017890)	3017890..3018359	-	470	Protein_2822	phage tail tube protein	-
JMW52_RS14560 (3018376)	3018376..3019686	-	1311	WP_009896640.1	phage tail sheath family protein	-
JMW52_RS14565 (3019687)	3019687..3019863	-	177	WP_009896638.1	hypothetical protein	-
JMW52_RS14570 (3019856)	3019856..3020053	-	198	WP_237774966.1	hypothetical protein	-
JMW52_RS14575 (3020068)	3020068..3020292	-	225	WP_237774967.1	hypothetical protein	-
JMW52_RS14580 (3020721)	3020721..3021266	-	546	WP_237774968.1	hypothetical protein	-
JMW52_RS14585 (3021554)	3021554..3021844	-	291	WP_009896634.1	HK97 gp10 family phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187277 WP_003424190.1 NZ_CP068558:c3017041-3016889 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187277 NZ_CP089780:3776246-3776503 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187277 NZ_CP068558:3016845-3016945 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin