Detailed information of TA system TA187274

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2399649..2399845
• Replicon: chromosome
• Accession: NZ_CP068557
• Organism: Clostridioides difficile strain CD4401

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW51_RS10890
• Protein ID: WP_003424190.1
• Coordinates: 2399649..2399801 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2399745..2399845 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW51_RS10865	2394734..2395375	+	642	WP_003424198.1	SdpI family protein	-
JMW51_RS10870	2395635..2395966	+	332	Protein_2058	carboxymuconolactone decarboxylase family protein	-
JMW51_RS10875	2396498..2396662	+	165	WP_003424195.1	hypothetical protein	-
JMW51_RS10880	2396886..2397731	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW51_RS10885	2398276..2398821	-	546	WP_077699404.1	site-specific integrase	-
JMW51_RS18185	2398887..2399129	-	243	WP_003424191.1	hypothetical protein	-
JMW51_RS10890	2399649..2399801	+	153	WP_003424190.1	hypothetical protein	Toxin
-	2399745..2399845	-	101	NuclAT_0	-	Antitoxin
JMW51_RS10895	2403792..2403980	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
JMW51_RS10900	2404168..2404401	+	234	WP_003424184.1	hypothetical protein	-
JMW51_RS10905	2404388..2404645	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187274 WP_003424190.1 NZ_CP068557:2399649-2399801 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187274 NZ_CP089780:3172960-3173403 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187274 NZ_CP068557:c2399845-2399745 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin