Detailed information of TA system TA187271

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1049364..1049560
• Replicon: chromosome
• Accession: NZ_CP068556
• Organism: Clostridioides difficile strain CD1801

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW48_RS04630
• Protein ID: WP_003424190.1
• Coordinates: 1049364..1049516 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1049460..1049560 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW48_RS04600	1044449..1045090	+	642	WP_003424198.1	SdpI family protein	-
JMW48_RS04605	1045350..1045681	+	332	Protein_914	carboxymuconolactone decarboxylase family protein	-
JMW48_RS04610	1046213..1046377	+	165	WP_003424195.1	hypothetical protein	-
JMW48_RS04615	1046601..1047446	-	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW48_RS04620	1047991..1048536	-	546	WP_077699404.1	site-specific integrase	-
JMW48_RS04625	1048602..1048844	-	243	WP_003424191.1	hypothetical protein	-
JMW48_RS04630	1049364..1049516	+	153	WP_003424190.1	hypothetical protein	Toxin
-	1049460..1049560	-	101	NuclAT_0	-	Antitoxin
JMW48_RS04635	1053440..1053628	-	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
JMW48_RS04640	1053816..1054049	+	234	WP_003424184.1	hypothetical protein	-
JMW48_RS04645	1054036..1054293	+	258	WP_003424182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(40) / ant(6)-Ia	-	1021850..1286675	264825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187271 WP_003424190.1 NZ_CP068556:1049364-1049516 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187271 NZ_CP089780:c3124171-3123287 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187271 NZ_CP068556:c1049560-1049460 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin