Detailed information of TA system TA187268

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3963165..3963361
• Replicon: chromosome
• Accession: NZ_CP068555
• Organism: Clostridioides difficile strain M120

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: JMW53_RS18095
• Protein ID: WP_003424190.1
• Coordinates: 3963209..3963361 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	3963165..3963265 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW53_RS18080	3958432..3958689	-	258	WP_003424182.1	hypothetical protein	-
JMW53_RS18085	3958676..3958909	-	234	WP_003424184.1	hypothetical protein	-
JMW53_RS18090	3959097..3959285	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
-	3963165..3963265	+	101	NuclAT_0	-	Antitoxin
JMW53_RS18095	3963209..3963361	-	153	WP_003424190.1	hypothetical protein	Toxin
JMW53_RS18100	3963881..3964123	+	243	WP_003424191.1	hypothetical protein	-
JMW53_RS18105	3964189..3964734	+	546	WP_077699404.1	site-specific integrase	-
JMW53_RS18110	3965279..3966124	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
JMW53_RS18115	3966348..3966512	-	165	WP_003424195.1	hypothetical protein	-
JMW53_RS18120	3967044..3967375	-	332	Protein_3494	carboxymuconolactone decarboxylase family protein	-
JMW53_RS18125	3967635..3968276	-	642	WP_003424198.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T187268 WP_003424190.1 NZ_CP068555:c3963361-3963209 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T187268 NZ_CP089780:c3066418-3066002 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT187268 NZ_CP068555:3963165-3963265 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin