187119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4626710..4627122 Replicon chromosome
Accession NZ_CP068283
Organism Escherichia coli strain CY598

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag JI738_RS22565 Protein ID WP_000132601.1
Coordinates 4626710..4627051 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4627046..4627122 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI738_RS22555 (4624123) 4624123..4625169 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
JI738_RS22560 (4625169) 4625169..4626548 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
JI738_RS22565 (4626710) 4626710..4627051 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4627046) 4627046..4627122 + 77 NuclAT_14 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_14 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_14 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_14 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_15 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_15 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_15 - Antitoxin
- (4627046) 4627046..4627122 + 77 NuclAT_15 - Antitoxin
JI738_RS22570 (4627279) 4627279..4628673 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
JI738_RS22575 (4628670) 4628670..4630259 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4619625..4628673 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T187119 WP_000132601.1 NZ_CP068283:c4627051-4626710 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T187119 NZ_CP089778:c756655-756347 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 77 bp

>AT187119 NZ_CP068283:4627046-4627122 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References