Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 1146332..1146744 Replicon chromosome
Accession NZ_CP068281
Organism Escherichia coli strain CY706

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag JJW04_RS05455 Protein ID WP_000132601.1
Coordinates 1146332..1146673 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 1146668..1146744 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW04_RS05445 (1143745) 1143745..1144791 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
JJW04_RS05450 (1144791) 1144791..1146170 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
JJW04_RS05455 (1146332) 1146332..1146673 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (1146668) 1146668..1146744 + 77 NuclAT_14 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_14 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_14 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_14 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_15 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_15 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_15 - Antitoxin
- (1146668) 1146668..1146744 + 77 NuclAT_15 - Antitoxin
JJW04_RS05460 (1146901) 1146901..1148295 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
JJW04_RS05465 (1148292) 1148292..1149881 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1139247..1148295 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T187038 WP_000132601.1 NZ_CP068281:c1146673-1146332 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T187038 NZ_CP089776:c3126508-3125624 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 77 bp

>AT187038 NZ_CP068281:1146668-1146744 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YSY7


Antitoxin

Download structure file

References