Detailed information of TA system TA181303

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3655164..3655399
• Replicon: chromosome
• Accession: NZ_CP064661
• Organism: Salmonella sp. SJTUF14178

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: IVP18_RS17895
• Protein ID: WP_051129376.1
• Coordinates: 3655172..3655399 (+)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3655164..3655389 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP18_RS17875	3651667..3652407	-	741	WP_051129375.1	pili assembly chaperone SafB	-
IVP18_RS17880	3652482..3652979	-	498	WP_064163159.1	Saf-pilin pilus formation protein SafA	-
IVP18_RS17885	3653112..3653606	-	495	WP_051129373.1	hypothetical protein	-
IVP18_RS17890	3654383..3655084	-	702	Protein_3501	IS481 family transposase	-
-	3655164..3655389	-	226	-	-	Antitoxin
IVP18_RS17895	3655172..3655399	+	228	WP_051129376.1	SymE family type I addiction module toxin	Toxin
IVP18_RS17900	3655445..3655909	-	465	WP_127201574.1	hypothetical protein	-
IVP18_RS17905	3656290..3657135	-	846	Protein_3504	RHS repeat protein	-
IVP18_RS17910	3657155..3657292	+	138	WP_023227287.1	hypothetical protein	-
IVP18_RS17915	3657435..3658043	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3635271..3679927	44656
	-	flank	IS/Tn	-	-	3654383..3654661	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-40)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8418.65 Da
• Isoelectric Point: 7.1623

>T181303 WP_051129376.1 NZ_CP064661:3655172-3655399 [Salmonella sp. SJTUF14178]
MTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVVNGN

Nucleotide

• Length: 228 bp

>T181303 NZ_CP085818:3577726-3578253 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Nucleotide

• Length: 226 bp

>AT181303 NZ_CP064661:c3655389-3655164 [Salmonella sp. SJTUF14178]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin