174646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 173837..174017 Replicon chromosome
Accession NZ_CP062368
Organism Staphylococcus aureus strain NAS_AN_115

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag IF712_RS01080 Protein ID WP_001801861.1
Coordinates 173922..174017 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 173837..173894 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF712_RS01050 169546..169680 + 135 WP_001791797.1 hypothetical protein -
IF712_RS01055 169844..171400 + 1557 WP_000028659.1 type I restriction-modification system subunit M -
IF712_RS01060 171393..172622 + 1230 WP_240021979.1 restriction endonuclease subunit S -
IF712_RS01065 173164..173574 + 411 WP_001808705.1 IS21 family transposase -
IF712_RS01070 173559..173720 + 162 Protein_175 transposase -
IF712_RS01075 173698..173799 - 102 WP_001792025.1 hypothetical protein -
- 173837..173894 + 58 - - Antitoxin
IF712_RS01080 173922..174017 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
IF712_RS01085 174162..175174 + 1013 Protein_178 IS3 family transposase -
IF712_RS01090 175372..175944 - 573 WP_000414216.1 hypothetical protein -
IF712_RS01095 176045..176386 - 342 WP_000627540.1 DUF3969 family protein -
IF712_RS01100 176427..177053 - 627 WP_000669024.1 hypothetical protein -
IF712_RS01105 177128..178123 - 996 WP_000070642.1 DUF4352 domain-containing protein -
IF712_RS01110 178204..178854 - 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / hlgA / lukD 147784..178818 31034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-44)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T174646 WP_001801861.1 NZ_CP062368:c174017-173922 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T174646 NZ_CP081307:c58795-58661 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 58 bp

>AT174646 NZ_CP062368:173837-173894 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References