Detailed information of TA system TA174517

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 173124..173304
• Replicon: chromosome
• Accession: NZ_CP062352
• Organism: Staphylococcus aureus strain NAS_AN_233

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF733_RS01080
• Protein ID: WP_001801861.1
• Coordinates: 173209..173304 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	173124..173181 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF733_RS01050	168833..168967	+	135	WP_001791797.1	hypothetical protein	-
IF733_RS01055	169131..170687	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
IF733_RS01060	170680..171909	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
IF733_RS01065	172451..172861	+	411	WP_001808705.1	IS21 family transposase	-
IF733_RS01070	172846..173007	+	162	Protein_175	transposase	-
IF733_RS01075	172985..173086	-	102	WP_001792025.1	hypothetical protein	-
-	173124..173181	+	58	-	-	Antitoxin
IF733_RS01080	173209..173304	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF733_RS01085	173449..174461	+	1013	Protein_178	IS3 family transposase	-
IF733_RS01090	174659..175231	-	573	WP_000414216.1	hypothetical protein	-
IF733_RS01095	175332..175673	-	342	WP_000627540.1	DUF3969 family protein	-
IF733_RS01100	175714..176340	-	627	WP_000669024.1	hypothetical protein	-
IF733_RS01105	176415..177410	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
IF733_RS01110	177491..178141	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002745 Staphylococcus aureus subsp. aureus N315 Prophage TA020384 1850940..1883547 0	inside	Prophage	-	selk / hlgA / lukD	146291..178899	32608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174517 WP_001801861.1 NZ_CP062352:c173304-173209 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174517 NZ_CP081175:2316248-2316985 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174517 NZ_CP062352:173124-173181 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin