173841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4570523..4570935 Replicon chromosome
Accession NZ_CP062243
Organism Escherichia coli strain AML003_ev03

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag IHN52_RS22020 Protein ID WP_000132601.1
Coordinates 4570523..4570864 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4570859..4570935 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN52_RS22010 4567936..4568982 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
IHN52_RS22015 4568982..4570361 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
IHN52_RS22020 4570523..4570864 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 4570859..4570935 + 77 NuclAT_14 - Antitoxin
- 4570859..4570935 + 77 NuclAT_14 - Antitoxin
- 4570859..4570935 + 77 NuclAT_14 - Antitoxin
- 4570859..4570935 + 77 NuclAT_14 - Antitoxin
- 4570859..4570935 + 77 NuclAT_15 - Antitoxin
- 4570859..4570935 + 77 NuclAT_15 - Antitoxin
- 4570859..4570935 + 77 NuclAT_15 - Antitoxin
- 4570859..4570935 + 77 NuclAT_15 - Antitoxin
IHN52_RS22025 4571092..4572486 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
IHN52_RS22030 4572483..4574072 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4563438..4572486 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T173841 WP_000132601.1 NZ_CP062243:c4570864-4570523 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T173841 NZ_CP080346:c4705204-4704920 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 77 bp

>AT173841 NZ_CP062243:4570859-4570935 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YSY7


Antitoxin

Download structure file

References