Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 1020925..1022162 | Replicon | chromosome |
| Accession | NZ_CP061208 | ||
| Organism | Streptococcus pneumoniae strain D39_P0 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | R4H7C0 |
| Locus tag | D39N_RS04995 | Protein ID | WP_000405357.1 |
| Coordinates | 1020925..1021686 (-) | Length | 254 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | D39N_RS05000 | Protein ID | WP_000579612.1 |
| Coordinates | 1021686..1022162 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D39N_RS04975 | 1016303..1018188 | - | 1886 | Protein_1001 | SAG1250 family conjugative relaxase | - |
| D39N_RS04980 (D39N_01005) | 1018211..1018540 | - | 330 | WP_000263037.1 | plasmid mobilization relaxosome protein MobC | - |
| D39N_RS04985 (D39N_01006) | 1018550..1018909 | - | 360 | WP_000529543.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| D39N_RS10555 (D39N_01007) | 1019741..1020118 | - | 378 | WP_249336495.1 | ATP-binding protein | - |
| D39N_RS04990 (D39N_01008) | 1020121..1020897 | - | 777 | WP_001821017.1 | hypothetical protein | - |
| D39N_RS04995 (D39N_01009) | 1020925..1021686 | - | 762 | WP_000405357.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| D39N_RS05000 (D39N_01010) | 1021686..1022162 | - | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| D39N_RS10560 | 1022607..1023062 | - | 456 | Protein_1008 | hypothetical protein | - |
| D39N_RS05015 (D39N_01013) | 1023337..1025076 | - | 1740 | WP_000423451.1 | glycoside hydrolase family 13 protein | - |
| D39N_RS05020 (D39N_01014) | 1025239..1026123 | - | 885 | WP_000710119.1 | diacylglycerol kinase family lipid kinase | - |
| D39N_RS05025 (D39N_01015) | 1026235..1027089 | - | 855 | WP_000900020.1 | ADP-ribosylglycohydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 1002451..1037417 | 34966 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 254 a.a. Molecular weight: 29044.10 Da Isoelectric Point: 7.1307
>T172266 WP_000405357.1 NZ_CP061208:c1021686-1020925 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
Download Length: 762 bp
>T172266 NZ_CP079692:c4934430-4934146 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT172266 WP_000579612.1 NZ_CP061208:c1022162-1021686 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT172266 NZ_CP079692:c4934662-4934420 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|