Detailed information of TA system TA171189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3565918..3566310
• Replicon: chromosome
• Accession: NZ_CP060852
• Organism: Salmonella enterica strain 467

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR30_RS17260
• Protein ID: WP_000994223.1
• Coordinates: 3566065..3566310 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3565918..3566274 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR30_RS17230	3561170..3561667	-	498	WP_165963407.1	pilus assembly protein	-
IAR30_RS17235	3562429..3563133	-	705	Protein_3374	integrase core domain-containing protein	-
IAR30_RS17240	3563186..3563500	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR30_RS17245	3563567..3563845	-	279	WP_133323248.1	hypothetical protein	-
IAR30_RS17250	3564163..3564630	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR30_RS17255	3565448..3565867	-	420	WP_131040133.1	hypothetical protein	-
-	3565918..3566274	-	357	-	-	Antitoxin
IAR30_RS17260	3566065..3566310	+	246	WP_000994223.1	hypothetical protein	Toxin
IAR30_RS17265	3566377..3566919	-	543	WP_079984650.1	hypothetical protein	-
IAR30_RS17270	3566919..3567254	-	336	WP_237117993.1	AHH domain-containing protein	-
IAR30_RS17275	3567273..3570940	-	3668	Protein_3382	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3553265..3567620	14355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171189 WP_000994223.1 NZ_CP060852:3566065-3566310 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171189 NZ_CP077858:2655767-2656018 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Nucleotide

• Length: 357 bp

>AT171189 NZ_CP060852:c3566274-3565918 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin