Detailed information of TA system TA171164

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 2351983..2352375
• Replicon: chromosome
• Accession: NZ_CP060849
• Organism: Salmonella enterica strain 724

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR31_RS11250
• Protein ID: WP_000994223.1
• Coordinates: 2351983..2352228 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2352019..2352375 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR31_RS11240	2347268..2351374	+	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-
IAR31_RS11245	2351374..2351916	+	543	WP_079984650.1	hypothetical protein	-
IAR31_RS11250	2351983..2352228	-	246	WP_000994223.1	hypothetical protein	Toxin
-	2352019..2352375	+	357	-	-	Antitoxin
IAR31_RS11255	2352426..2352845	+	420	WP_131040133.1	hypothetical protein	-
IAR31_RS11260	2353663..2354130	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR31_RS11265	2354448..2354726	+	279	WP_133323248.1	hypothetical protein	-
IAR31_RS11270	2354793..2355107	-	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR31_RS11275	2355160..2355864	+	705	Protein_2187	integrase core domain-containing protein	-
IAR31_RS11280	2356626..2357123	+	498	WP_165963407.1	pilus assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171164 WP_000994223.1 NZ_CP060849:c2352228-2351983 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171164 NZ_CP077856:2492349-2492453 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT171164 NZ_CP060849:2352019-2352375 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin