Detailed information of TA system TA171151

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3533154..3533546
• Replicon: chromosome
• Accession: NZ_CP060846
• Organism: Salmonella enterica strain 733

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR32_RS17120
• Protein ID: WP_000994223.1
• Coordinates: 3533301..3533546 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3533154..3533510 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR32_RS17090	3528406..3528903	-	498	WP_165963407.1	pilus assembly protein	-
IAR32_RS17095	3529665..3530369	-	705	Protein_3346	integrase core domain-containing protein	-
IAR32_RS17100	3530422..3530736	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR32_RS17105	3530803..3531081	-	279	WP_133323248.1	hypothetical protein	-
IAR32_RS17110	3531399..3531866	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR32_RS17115	3532684..3533103	-	420	WP_131040133.1	hypothetical protein	-
-	3533154..3533510	-	357	-	-	Antitoxin
IAR32_RS17120	3533301..3533546	+	246	WP_000994223.1	hypothetical protein	Toxin
IAR32_RS17125	3533613..3534155	-	543	WP_079984650.1	hypothetical protein	-
IAR32_RS17130	3534155..3538261	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3520501..3534155	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171151 WP_000994223.1 NZ_CP060846:3533301-3533546 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171151 NZ_CP077855:424229-424405 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT171151 NZ_CP060846:c3533510-3533154 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin