Detailed information of TA system TA171114

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3502277..3502669
• Replicon: chromosome
• Accession: NZ_CP060840
• Organism: Salmonella enterica strain 805

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: IAR34_RS16885
• Protein ID: WP_241467015.1
• Coordinates: 3502424..3502669 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3502277..3502633 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR34_RS16855	3497529..3498026	-	498	WP_165963407.1	pilus assembly protein	-
IAR34_RS16860	3498788..3499492	-	705	Protein_3299	integrase core domain-containing protein	-
IAR34_RS16865	3499545..3499859	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR34_RS16870	3499926..3500204	-	279	WP_133323248.1	hypothetical protein	-
IAR34_RS16875	3500522..3500989	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR34_RS16880	3501807..3502226	-	420	WP_131040133.1	hypothetical protein	-
-	3502277..3502633	-	357	-	-	Antitoxin
IAR34_RS16885	3502424..3502669	+	246	WP_241467015.1	hypothetical protein	Toxin
IAR34_RS16890	3502736..3503278	-	543	WP_079984650.1	hypothetical protein	-
IAR34_RS16895	3503278..3507384	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3489624..3503278	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8848.00 Da
• Isoelectric Point: 4.0543

>T171114 WP_241467015.1 NZ_CP060840:3502424-3502669 [Salmonella enterica]
MNASDVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171114 NZ_CP077852:c92402-92226 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT171114 NZ_CP060840:c3502633-3502277 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGTCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Antitoxin