Detailed information of TA system TA171095

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3545780..3546172
• Replicon: chromosome
• Accession: NZ_CP060837
• Organism: Salmonella enterica strain 852

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR35_RS17195
• Protein ID: WP_000994223.1
• Coordinates: 3545927..3546172 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3545780..3546136 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR35_RS17165	3541032..3541529	-	498	WP_165963407.1	pilus assembly protein	-
IAR35_RS17170	3542291..3542995	-	705	Protein_3361	integrase core domain-containing protein	-
IAR35_RS17175	3543048..3543362	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR35_RS17180	3543429..3543707	-	279	WP_133323248.1	hypothetical protein	-
IAR35_RS17185	3544025..3544492	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR35_RS17190	3545310..3545729	-	420	WP_131040133.1	hypothetical protein	-
-	3545780..3546136	-	357	-	-	Antitoxin
IAR35_RS17195	3545927..3546172	+	246	WP_000994223.1	hypothetical protein	Toxin
IAR35_RS17200	3546239..3546781	-	543	WP_079984650.1	hypothetical protein	-
IAR35_RS17205	3546781..3550887	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3533127..3546781	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171095 WP_000994223.1 NZ_CP060837:3545927-3546172 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171095 NZ_CP077839:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Nucleotide

• Length: 357 bp

>AT171095 NZ_CP060837:c3546136-3545780 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin