Detailed information of TA system TA171076

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3534292..3534684
• Replicon: chromosome
• Accession: NZ_CP060834
• Organism: Salmonella enterica strain 1505

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR36_RS17130
• Protein ID: WP_000994223.1
• Coordinates: 3534439..3534684 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3534292..3534648 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR36_RS17100	3529544..3530041	-	498	WP_165963407.1	pilus assembly protein	-
IAR36_RS17105	3530803..3531507	-	705	Protein_3348	integrase core domain-containing protein	-
IAR36_RS17110	3531560..3531874	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR36_RS17115	3531941..3532219	-	279	WP_133323248.1	hypothetical protein	-
IAR36_RS17120	3532537..3533004	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR36_RS17125	3533822..3534241	-	420	WP_131040133.1	hypothetical protein	-
-	3534292..3534648	-	357	-	-	Antitoxin
IAR36_RS17130	3534439..3534684	+	246	WP_000994223.1	hypothetical protein	Toxin
IAR36_RS17135	3534751..3535293	-	543	WP_079984650.1	hypothetical protein	-
IAR36_RS17140	3535293..3539399	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3521639..3535293	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171076 WP_000994223.1 NZ_CP060834:3534439-3534684 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171076 NZ_CP077824:c4816948-4816580 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 357 bp

>AT171076 NZ_CP060834:c3534648-3534292 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin