170198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2255435..2255615 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag H7684_RS10775 Protein ID WP_001801861.1
Coordinates 2255435..2255530 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2255558..2255615 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS10745 2250598..2251248 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
H7684_RS10750 2251329..2252324 + 996 WP_000070642.1 DUF4352 domain-containing protein -
H7684_RS10755 2252399..2253025 + 627 WP_000669024.1 hypothetical protein -
H7684_RS10760 2253066..2253407 + 342 WP_000627540.1 DUF3969 family protein -
H7684_RS10765 2253508..2254080 + 573 WP_000414216.1 hypothetical protein -
H7684_RS10770 2254278..2255290 - 1013 Protein_2132 IS3 family transposase -
H7684_RS10775 2255435..2255530 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2255558..2255615 - 58 - - Antitoxin
H7684_RS10780 2255653..2255754 + 102 WP_001792025.1 hypothetical protein -
H7684_RS10785 2255732..2255893 - 162 Protein_2135 transposase -
H7684_RS10790 2255878..2256288 - 411 WP_001808705.1 IS21 family transposase -
H7684_RS10795 2256830..2258059 - 1230 WP_000072627.1 restriction endonuclease subunit S -
H7684_RS10800 2258052..2259608 - 1557 WP_071621388.1 type I restriction-modification system subunit M -
H7684_RS10805 2259772..2259906 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2250634..2291412 40778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T170198 WP_001801861.1 NZ_CP060278:2255435-2255530 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T170198 NZ_CP077198:c529053-528775 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAACGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
AGAAAAAACAGATGAGCTCATAGAAGCCAAAGTTGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCCGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 58 bp

>AT170198 NZ_CP060278:c2255615-2255558 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References