Detailed information of TA system TA167124

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 2783327..2783588
• Replicon: chromosome
• Accession: NZ_CP058671
• Organism: Salmonella enterica strain MS114

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: HWV51_RS13695
• Protein ID: WP_022630712.1
• Coordinates: 2783361..2783588 (+)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2783327..2783578 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWV51_RS13670	2778636..2780206	+	1571	Protein_2674	IS66 family transposase	-
HWV51_RS13675	2780462..2780695	-	234	WP_129589482.1	hypothetical protein	-
HWV51_RS13680	2781029..2781274	+	246	WP_000994223.1	hypothetical protein	-
HWV51_RS13685	2781338..2781784	-	447	WP_000171103.1	hypothetical protein	-
HWV51_RS13690	2781781..2783280	-	1500	Protein_2678	RHS repeat-associated core domain-containing protein	-
-	2783327..2783578	-	252	-	-	Antitoxin
HWV51_RS13695	2783361..2783588	+	228	WP_022630712.1	SymE family type I addiction module toxin	Toxin
HWV51_RS13700	2783635..2784069	-	435	WP_000789494.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8354.60 Da
• Isoelectric Point: 8.0260

>T167124 WP_022630712.1 NZ_CP058671:2783361-2783588 [Salmonella enterica]
MTTYYSRIPSLHLKGDWLTEAGFDTGASVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGN

Nucleotide

• Length: 228 bp

>T167124 NZ_CP074693:c1682629-1682405 [Geobacter sulfurreducens]
ATGATTGAAATCCGCAAAACCGAACTGTTTGCCAAATGGCTTGACAATCTTCGTGATGTAAAGGCCAAGGCTCGGGTCCT
CGTGAGGATTGAGCGGCTTGCGTCCGGAAATCCCGGAGACGTCAAACCGGTCGGCGATGGAATCTCGGAAATGCGTATCG
ACTACGGTCCTGGTTACCGAGTTTATTTCTTCCAGCGAGGAAGCGAATTTGGCCGGCGGCGATAA

Antitoxin

Nucleotide

• Length: 252 bp

>AT167124 NZ_CP058671:c2783578-2783327 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAAATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACTGTCACGCTCGCGCCGGTATCAAATCCCGCTT
CTGTCAGCCAGTCACCCTTGAGATGCAGGCTGGGAATGCGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTCTCGTGG
CGGACGCTGACG

Structures

Antitoxin