Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1172037..1173538 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag HWS75_RS05605 Protein ID WP_003898703.1
Coordinates 1172657..1173538 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag HWS75_RS05600 Protein ID WP_003405517.1
Coordinates 1172037..1172660 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS05580 1167533..1168360 - 828 WP_003405370.1 PE domain-containing protein -
HWS75_RS05585 1169148..1169387 - 240 WP_003405375.1 hypothetical protein -
HWS75_RS05590 1169556..1170483 - 928 Protein_1102 IS5-like element ISMt1 family transposase -
HWS75_RS05595 1170765..1171790 - 1026 WP_003405514.1 serine protease -
HWS75_RS05600 1172037..1172660 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
HWS75_RS05605 1172657..1173538 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HWS75_RS05610 1174408..1175655 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
HWS75_RS05615 1176023..1177138 - 1116 WP_003405582.1 hypothetical protein -
HWS75_RS05620 1177095..1177298 - 204 WP_003405585.1 hypothetical protein -
HWS75_RS05625 1177371..1177817 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1163902..1175655 11753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T166338 WP_003898703.1 NZ_CP058236:1172657-1173538 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T166338 NZ_CP074137:619192-619389 [Serratia sp. JSRIV006]
ATGCGCATCGAATGGGACGACGTTGCGTTGCAAGATCGGGAACGCATTTTTGAATTTCTTTATCCACCCAATTCATTGGC
CGCGGAACAAGTTGATGATGAGATTGAACTTGCCGTTGAGTCTCTGCTAGAAAACCCAGAAATGGTTAGGCTCACAAGCT
TTGTTAGCGCACAATTATTCAATAATAAAAACATATAA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT166338 WP_003405517.1 NZ_CP058236:1172037-1172660 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT166338 NZ_CP074137:618896-619183 [Serratia sp. JSRIV006]
ATGGAAAGCCGTATCCAGTTTCGCATTGAAAATGAAACTAAACTGTTGGCACAGAAAGCTGCTGAAGCGAAAGGGACGAC
CTTAAGTGAAGCCTGTCGGCGTTTAGCGCAACAAATGGCGGACGATCAACGTGCTGCTGAAGAACACGAAAACTGGTTGA
AAGATAAGGTTGATGCAGCCTTTGCCCGTTTGCATGAAGGAGAGGCTGTTTATCTTACCCAGCGGCAAGCTGAGGAGAGA
ATGAGCGACTTTAAAGCCAAAGTCAGGGCGAAATACGCAACCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References