160069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4631290..4631702 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag HUR94_RS22635 Protein ID WP_000132601.1
Coordinates 4631290..4631631 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4631626..4631702 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS22625 (4628703) 4628703..4629749 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
HUR94_RS22630 (4629749) 4629749..4631128 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
HUR94_RS22635 (4631290) 4631290..4631631 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4631626) 4631626..4631702 + 77 NuclAT_14 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_14 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_14 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_14 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_15 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_15 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_15 - Antitoxin
- (4631626) 4631626..4631702 + 77 NuclAT_15 - Antitoxin
HUR94_RS22640 (4631859) 4631859..4633253 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
HUR94_RS22645 (4633250) 4633250..4634839 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4624205..4633253 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T160069 WP_000132601.1 NZ_CP054665:c4631631-4631290 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T160069 NZ_CP070287:c4569183-4568872 [Escherichia albertii]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 77 bp

>AT160069 NZ_CP054665:4631626-4631702 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References