Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4094793..4095463 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag FOC64_RS19210 Protein ID WP_003899954.1
Coordinates 4095119..4095463 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag FOC64_RS19205 Protein ID WP_003899955.1
Coordinates 4094793..4095122 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS19180 4090208..4091242 + 1035 WP_003416786.1 IS30 family transposase -
FOC64_RS19185 4091489..4091698 - 210 WP_003416778.1 hypothetical protein -
FOC64_RS19190 4091866..4093131 + 1266 WP_003902423.1 hypothetical protein -
FOC64_RS19195 4093291..4093911 - 621 WP_003899957.1 RES family NAD+ phosphorylase -
FOC64_RS19200 4093908..4094255 - 348 WP_003899956.1 DUF2384 domain-containing protein -
FOC64_RS19205 4094793..4095122 - 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
FOC64_RS19210 4095119..4095463 - 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC64_RS19215 4095694..4096146 + 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC64_RS19220 4096149..4096583 + 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS19225 4096692..4097953 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FOC64_RS19230 4098288..4099577 - 1290 WP_003416640.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4077036..4101157 24121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T158511 WP_003899954.1 NZ_CP054014:c4095463-4095119 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T158511 NZ_CP069657:c1173936-1173559 [Escherichia coli O89m:H10]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT158511 WP_003899955.1 NZ_CP054014:c4095122-4094793 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT158511 NZ_CP069657:c1174394-1174026 [Escherichia coli O89m:H10]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References