Detailed information of TA system TA157308

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 218277..218457
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HA033_RS01435
• Protein ID: WP_001801861.1
• Coordinates: 218362..218457 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	218277..218334 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS01405	213986..214120	+	135	WP_001791797.1	hypothetical protein	-
HA033_RS01410	214284..215840	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
HA033_RS01415	215833..217062	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
HA033_RS01420	217514..218008	+	495	Protein_244	transposase	-
HA033_RS01425	217999..218160	+	162	Protein_245	transposase	-
HA033_RS01430	218138..218239	-	102	WP_001792025.1	hypothetical protein	-
-	218277..218334	+	58	-	-	Antitoxin
HA033_RS01435	218362..218457	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
HA033_RS01440	218602..219614	+	1013	Protein_248	IS3 family transposase	-
HA033_RS01445	219812..220384	-	573	WP_000414216.1	hypothetical protein	-
HA033_RS01450	220485..220826	-	342	WP_000627540.1	DUF3969 family protein	-
HA033_RS01455	220867..221493	-	627	WP_000669024.1	hypothetical protein	-
HA033_RS01460	221568..222563	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
HA033_RS01465	222644..223294	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002745 Staphylococcus aureus subsp. aureus N315 Prophage TA020384 1850940..1883547 0	inside	Prophage	-	selk / hlgA / lukD	191445..224053	32608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T157308 WP_001801861.1 NZ_CP053640:c218457-218362 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T157308 NZ_CP069133:2759277-2760350 [Escherichia coli BW25113]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT157308 NZ_CP053640:218277-218334 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin