Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4523262..4523674 Replicon chromosome
Accession NZ_CP053607
Organism Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag HO392_RS21800 Protein ID WP_000132601.1
Coordinates 4523262..4523603 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4523598..4523674 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO392_RS21790 4520675..4521721 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
HO392_RS21795 4521721..4523100 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
HO392_RS21800 4523262..4523603 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 4523598..4523674 + 77 NuclAT_14 - Antitoxin
- 4523598..4523674 + 77 NuclAT_14 - Antitoxin
- 4523598..4523674 + 77 NuclAT_14 - Antitoxin
- 4523598..4523674 + 77 NuclAT_14 - Antitoxin
- 4523598..4523674 + 77 NuclAT_15 - Antitoxin
- 4523598..4523674 + 77 NuclAT_15 - Antitoxin
- 4523598..4523674 + 77 NuclAT_15 - Antitoxin
- 4523598..4523674 + 77 NuclAT_15 - Antitoxin
HO392_RS21805 4523831..4525225 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
HO392_RS21810 4525222..4526811 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4516177..4525225 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T157200 WP_000132601.1 NZ_CP053607:c4523603-4523262 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T157200 NZ_CP069078:712033-712440 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 77 bp

>AT157200 NZ_CP053607:4523598-4523674 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References