Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4565889..4566301 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag HO395_RS21930 Protein ID WP_000132601.1
Coordinates 4565889..4566230 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4566225..4566301 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS21920 4563302..4564348 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
HO395_RS21925 4564348..4565727 - 1380 Protein_4265 5-methylcytosine-specific restriction endonuclease subunit McrB -
HO395_RS21930 4565889..4566230 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 4566225..4566301 + 77 NuclAT_14 - Antitoxin
- 4566225..4566301 + 77 NuclAT_14 - Antitoxin
- 4566225..4566301 + 77 NuclAT_14 - Antitoxin
- 4566225..4566301 + 77 NuclAT_14 - Antitoxin
- 4566225..4566301 + 77 NuclAT_15 - Antitoxin
- 4566225..4566301 + 77 NuclAT_15 - Antitoxin
- 4566225..4566301 + 77 NuclAT_15 - Antitoxin
- 4566225..4566301 + 77 NuclAT_15 - Antitoxin
HO395_RS21935 4566458..4567852 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
HO395_RS21940 4567849..4569438 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4558804..4567852 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T157088 WP_000132601.1 NZ_CP053603:c4566230-4565889 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T157088 NZ_CP069076:838494-838922 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 77 bp

>AT157088 NZ_CP053603:4566225-4566301 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References