155920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1919832..1920012 Replicon chromosome
Accession NZ_CP053075
Organism Staphylococcus aureus strain SA01

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag HK402_RS09410 Protein ID WP_001801861.1
Coordinates 1919832..1919927 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1919955..1920012 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK402_RS09380 1914995..1915645 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
HK402_RS09385 1915726..1916721 + 996 WP_000070642.1 DUF4352 domain-containing protein -
HK402_RS09390 1916796..1917422 + 627 WP_000669024.1 hypothetical protein -
HK402_RS09395 1917463..1917804 + 342 WP_000627540.1 DUF3969 family protein -
HK402_RS09400 1917905..1918477 + 573 WP_170172375.1 hypothetical protein -
HK402_RS09405 1918675..1919687 - 1013 Protein_1850 IS3 family transposase -
HK402_RS09410 1919832..1919927 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1919955..1920012 - 58 - - Antitoxin
HK402_RS09415 1920050..1920151 + 102 WP_001792025.1 hypothetical protein -
HK402_RS09420 1920129..1920290 - 162 Protein_1853 transposase -
HK402_RS09425 1920281..1920775 - 495 Protein_1854 transposase -
HK402_RS09430 1921227..1922456 - 1230 WP_000072627.1 restriction endonuclease subunit S -
HK402_RS09435 1922449..1924005 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
HK402_RS09440 1924169..1924303 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1914237..1946843 32606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T155920 WP_001801861.1 NZ_CP053075:1919832-1919927 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T155920 NZ_CP068820:1432723-1433109 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 58 bp

>AT155920 NZ_CP053075:c1920012-1919955 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References