Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 297193..298781 Replicon chromosome
Accession NZ_CP051719
Organism Escherichia coli strain SCU-116

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag HHJ31_RS01550 Protein ID WP_001125475.1
Coordinates 297193..298515 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HHJ31_RS01555 Protein ID WP_001332145.1
Coordinates 298515..298781 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ31_RS01525 292490..293332 - 843 Protein_298 fimbrial biogenesis outer membrane usher protein -
HHJ31_RS01530 293374..294084 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
HHJ31_RS01535 294446..295009 - 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
HHJ31_RS01540 295785..296567 - 783 WP_001221834.1 SDR family oxidoreductase -
HHJ31_RS01545 296677..296934 + 258 WP_001210030.1 hypothetical protein -
HHJ31_RS01550 297193..298515 - 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HHJ31_RS01555 298515..298781 - 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HHJ31_RS01560 299089..299847 + 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
HHJ31_RS01565 299851..300765 - 915 WP_001306069.1 bestrophin family protein -
HHJ31_RS01570 300962..302413 - 1452 WP_001513806.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimA 281328..298781 17453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T155004 WP_001125475.1 NZ_CP051719:c298515-297193 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T155004 NZ_CP068591:c2182096-2181989 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGACGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT155004 WP_001332145.1 NZ_CP051719:c298781-298515 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT155004 NZ_CP068591:2182143-2182209 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References