Detailed information of TA system TA153840

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3820171..3820406
• Replicon: chromosome
• Accession: NZ_CP051218
• Organism: Salmonella sp. SCFS4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: HF553_RS18680
• Protein ID: WP_051129376.1
• Coordinates: 3820179..3820406 (+)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3820171..3820396 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF553_RS18660	3816683..3817423	-	741	WP_051129375.1	pili assembly chaperone SafB	-
HF553_RS18665	3817498..3817995	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
HF553_RS18670	3818128..3818622	-	495	WP_051129373.1	hypothetical protein	-
HF553_RS18675	3819390..3820091	-	702	Protein_3660	IS481 family transposase	-
-	3820171..3820396	-	226	-	-	Antitoxin
HF553_RS18680	3820179..3820406	+	228	WP_051129376.1	SymE family type I addiction module toxin	Toxin
HF553_RS18685	3820452..3820916	-	465	WP_127201574.1	hypothetical protein	-
HF553_RS18690	3820913..3821125	-	213	Protein_3663	hypothetical protein	-
HF553_RS18695	3821300..3822160	-	861	Protein_3664	RHS repeat protein	-
HF553_RS18700	3822162..3822299	+	138	WP_023227287.1	hypothetical protein	-
HF553_RS18705	3822442..3823050	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3800287..3842816	42529
	-	flank	IS/Tn	-	-	3819390..3819668	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-40)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8418.65 Da
• Isoelectric Point: 7.1623

>T153840 WP_051129376.1 NZ_CP051218:3820179-3820406 [Salmonella sp. SCFS4]
MTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVVNGN

Nucleotide

• Length: 228 bp

>T153840 NZ_CP067232:c2283695-2283231 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 226 bp

>AT153840 NZ_CP051218:c3820396-3820171 [Salmonella sp. SCFS4]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin