153110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2388844..2389024 Replicon chromosome
Accession NZ_CP050691
Organism Staphylococcus aureus strain PMB196-1

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag HCU71_RS11420 Protein ID WP_001801861.1
Coordinates 2388844..2388939 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2388967..2389024 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU71_RS11390 2384007..2384657 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
HCU71_RS11395 2384738..2385733 + 996 WP_000070642.1 DUF4352 domain-containing protein -
HCU71_RS11400 2385808..2386434 + 627 WP_000669024.1 hypothetical protein -
HCU71_RS11405 2386475..2386816 + 342 WP_000627540.1 DUF3969 family protein -
HCU71_RS11410 2386917..2387489 + 573 WP_000414216.1 hypothetical protein -
HCU71_RS11415 2387687..2388699 - 1013 Protein_2236 IS3 family transposase -
HCU71_RS11420 2388844..2388939 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2388967..2389024 - 58 - - Antitoxin
HCU71_RS11425 2389062..2389163 + 102 WP_001792025.1 hypothetical protein -
HCU71_RS11430 2389141..2389302 - 162 Protein_2239 transposase -
HCU71_RS11435 2389293..2389787 - 495 Protein_2240 transposase -
HCU71_RS11440 2390239..2391468 - 1230 WP_000072627.1 restriction endonuclease subunit S -
HCU71_RS11445 2391461..2393017 - 1557 WP_209308239.1 type I restriction-modification system subunit M -
HCU71_RS11450 2393181..2393315 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2383249..2415856 32607


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T153110 WP_001801861.1 NZ_CP050691:2388844-2388939 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T153110 NZ_CP066757:14520-14825 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 58 bp

>AT153110 NZ_CP050691:c2389024-2388967 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References