Detailed information of TA system TA151896

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 3865841..3866060
• Replicon: chromosome
• Accession: NZ_CP049958
• Organism: Clostridioides difficile strain CFSAN096664

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: GLV80_RS17805
• Protein ID: WP_009901465.1
• Coordinates: 3865899..3866060 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	3865841..3865979 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLV80_RS17790	3861641..3862330	-	690	WP_009901477.1	LysM peptidoglycan-binding domain-containing protein	-
GLV80_RS17795	3862346..3864715	-	2370	WP_009901478.1	tape measure protein	-
GLV80_RS17800	3864782..3865552	-	771	WP_018112719.1	SHOCT domain-containing protein	-
-	3865841..3865979	+	139	NuclAT_2	-	Antitoxin
-	3865841..3865979	+	139	NuclAT_5	-	Antitoxin
GLV80_RS17805	3865899..3866060	-	162	WP_009901465.1	hypothetical protein	Toxin
GLV80_RS17810	3866381..3866821	-	441	WP_009901463.1	phage portal protein	-
GLV80_RS17815	3866823..3867080	-	258	WP_009901462.1	hypothetical protein	-
GLV80_RS17820	3867133..3867609	-	477	WP_009901461.1	phage tail tube protein	-
GLV80_RS17825	3867628..3868938	-	1311	WP_009901460.1	phage tail sheath family protein	-
GLV80_RS17830	3868939..3869115	-	177	WP_009901459.1	hypothetical protein	-
GLV80_RS17835	3869108..3869545	-	438	WP_009901457.1	hypothetical protein	-
GLV80_RS17840	3869538..3869963	-	426	WP_009896626.1	HK97 gp10 family phage protein	-
GLV80_RS17845	3869963..3870310	-	348	WP_015984843.1	hypothetical protein	-
GLV80_RS17850	3870304..3870705	-	402	WP_015984842.1	hypothetical protein	-
GLV80_RS17855	3870715..3870948	-	234	WP_003429842.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T151896 WP_009901465.1 NZ_CP049958:c3866060-3865899 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T151896 NZ_CP065831:1538278-1538760 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAAACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGTCGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTAAAACTTCCA
TAA

Antitoxin

Nucleotide

• Length: 139 bp

>AT151896 NZ_CP049958:3865841-3865979 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAATATAAATTATTTAAATTTGCGGAACTTT
ATTTTAAAGCCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin