Detailed information of TA system TA151894

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2533566..2533762
• Replicon: chromosome
• Accession: NZ_CP049958
• Organism: Clostridioides difficile strain CFSAN096664

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: Q18BT8
• Locus tag: GLV80_RS11880
• Protein ID: WP_009902496.1
• Coordinates: 2533610..2533762 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2533566..2533666 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLV80_RS11870	2529894..2530739	+	846	WP_009902498.1	GGDEF domain-containing protein	-
GLV80_RS11875	2530979..2532712	+	1734	WP_009902497.1	diguanylate cyclase	-
-	2533566..2533666	+	101	NuclAT_11	-	Antitoxin
GLV80_RS11880	2533610..2533762	-	153	WP_009902496.1	hypothetical protein	Toxin
GLV80_RS11885	2534899..2536254	+	1356	WP_003438549.1	MATE family efflux transporter	-
GLV80_RS11890	2536372..2537040	-	669	WP_032507408.1	diphthine--ammonia ligase	-
GLV80_RS11895	2537107..2537535	-	429	WP_003429356.1	DMT family transporter	-
GLV80_RS11900	2537642..2538235	+	594	WP_003438546.1	DUF308 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5742.81 Da
• Isoelectric Point: 10.9178

>T151894 WP_009902496.1 NZ_CP049958:c2533762-2533610 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Nucleotide

• Length: 153 bp

>T151894 NZ_CP065831:349412-349759 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGAATACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 101 bp

>AT151894 NZ_CP049958:2533566-2533666 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A069ACY9

Antitoxin