Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) CD-RCd/-
Location 2330451..2330665 Replicon chromosome
Accession NZ_CP049958
Organism Clostridioides difficile strain CFSAN096664

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag GLV80_RS10880 Protein ID WP_003429855.1
Coordinates 2330504..2330665 (-) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 2330451..2330584 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLV80_RS10870 2326063..2328351 - 2289 WP_025991999.1 tape measure protein -
GLV80_RS10875 2328423..2329304 - 882 WP_009901511.1 hypothetical protein -
- 2330001..2330106 + 106 NuclAT_8 - -
- 2330001..2330106 + 106 NuclAT_9 - -
- 2330451..2330584 + 134 NuclAT_1 - Antitoxin
- 2330451..2330584 + 134 NuclAT_4 - Antitoxin
GLV80_RS10880 2330504..2330665 - 162 WP_003429855.1 hypothetical protein Toxin
GLV80_RS10885 2331006..2331446 - 441 WP_003429853.1 phage portal protein -
GLV80_RS10890 2331518..2331988 - 471 WP_003429851.1 phage tail tube protein -
GLV80_RS10895 2332005..2333315 - 1311 WP_009901508.1 phage tail sheath family protein -
GLV80_RS10900 2333316..2333492 - 177 WP_009901506.1 hypothetical protein -
GLV80_RS10905 2333485..2333922 - 438 WP_009901504.1 hypothetical protein -
GLV80_RS10910 2333915..2334340 - 426 WP_003429845.1 HK97 gp10 family phage protein -
GLV80_RS10915 2334340..2334687 - 348 WP_003429844.1 hypothetical protein -
GLV80_RS10920 2334681..2335082 - 402 WP_021379034.1 hypothetical protein -
GLV80_RS10925 2335092..2335325 - 234 WP_009896624.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T151890 WP_003429855.1 NZ_CP049958:c2330665-2330504 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T151890 NZ_CP065825:c4744381-4743464 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 134 bp

>AT151890 NZ_CP049958:2330451-2330584 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A069AVN2


Antitoxin

Download structure file

References