Detailed information of TA system TA151887

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1507013..1507215
• Replicon: chromosome
• Accession: NZ_CP049958
• Organism: Clostridioides difficile strain CFSAN096664

Toxin (Protein)

• Gene name: CD2299.1
• Uniprot ID: Q185H1
• Locus tag: GLV80_RS07090
• Protein ID: WP_004454589.1
• Coordinates: 1507013..1507165 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ1641
Locus tag	-
Coordinates	1507086..1507215 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLV80_RS07055	1502182..1502352	-	171	WP_021394397.1	hypothetical protein	-
GLV80_RS07060	1502741..1503229	-	489	WP_009897487.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
GLV80_RS07065	1504033..1504407	+	375	WP_004454597.1	BlaI/MecI/CopY family transcriptional regulator	-
GLV80_RS07070	1504512..1504886	+	375	Protein_1304	BlaI/MecI/CopY family transcriptional regulator	-
GLV80_RS07075	1505176..1505694	+	519	Protein_1305	transposase	-
GLV80_RS07080	1506126..1506380	+	255	WP_004454592.1	hypothetical protein	-
GLV80_RS07085	1506416..1506739	+	324	WP_009897482.1	hypothetical protein	-
GLV80_RS07090	1507013..1507165	+	153	WP_004454589.1	hypothetical protein	Toxin
-	1507086..1507215	-	130	NuclAT_7	-	Antitoxin
GLV80_RS07095	1507359..1508243	+	885	WP_009897481.1	hypothetical protein	-
GLV80_RS07100	1509292..1509444	+	153	WP_009897477.1	hypothetical protein	-
GLV80_RS07105	1509564..1510378	+	815	Protein_1311	toxin Bro	-
GLV80_RS07110	1510430..1510591	+	162	WP_004454578.1	hypothetical protein	-
GLV80_RS07115	1510920..1511384	-	465	WP_004454576.1	hypothetical protein	-
GLV80_RS07120	1511520..1511837	-	318	WP_009897465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.92 Da
• Isoelectric Point: 10.6365

>T151887 WP_004454589.1 NZ_CP049958:1507013-1507165 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Nucleotide

• Length: 153 bp

>T151887 NZ_CP065825:4065661-4066029 [Klebsiella pneumoniae]
ATGAAAAATCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCATCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGTGATGAAGCCGTTATACAGGAACATATTG
ATGCCGGTATCACTCTGGCTAATGCTGTTAACTTTCTGGTGGAGAAGTATGAGTTAGTCCGTATCGATCGCTGTGGATTT
TCCTCACAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCATGCCAGGAAAGCGTGCGGGCTGATGAGCCGGTA
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGATATGA

Antitoxin

Nucleotide

• Length: 130 bp

>AT151887 NZ_CP049958:c1507215-1507086 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Structures

Toxin

• AlphaFold DB: A0A125V725

Antitoxin