Detailed information of TA system TA151884

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1261254..1261463
• Replicon: chromosome
• Accession: NZ_CP049958
• Organism: Clostridioides difficile strain CFSAN096664

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: Q182K5
• Locus tag: GLV80_RS05955
• Protein ID: WP_004454815.1
• Coordinates: 1261254..1261412 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	1261329..1261463 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLV80_RS05925	1257050..1257718	+	669	WP_009897711.1	VanZ family protein	-
GLV80_RS05930	1257758..1257838	+	81	Protein_1077	VOC family protein	-
GLV80_RS05935	1258201..1258473	-	273	WP_004454820.1	tyrosine-type recombinase/integrase	-
GLV80_RS05940	1258704..1259125	-	422	Protein_1079	hypothetical protein	-
GLV80_RS05945	1259144..1259242	-	99	Protein_1080	Arm DNA-binding domain-containing protein	-
GLV80_RS05950	1259525..1260895	+	1371	WP_009903221.1	cell wall-binding protein Cwp29	-
GLV80_RS05955	1261254..1261412	+	159	WP_004454815.1	hypothetical protein	Toxin
-	1261329..1261463	-	135	NuclAT_0	-	Antitoxin
GLV80_RS05960	1262858..1263241	+	384	Protein_1083	BlaI/MecI/CopY family transcriptional regulator	-
GLV80_RS05965	1263430..1264425	-	996	WP_003431031.1	asparaginase	-
GLV80_RS05970	1264546..1266174	-	1629	WP_009897704.1	aspartate 4-decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5996.20 Da
• Isoelectric Point: 11.3102

>T151884 WP_004454815.1 NZ_CP049958:1261254-1261412 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T151884 NZ_CP065825:1837429-1837531 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 135 bp

>AT151884 NZ_CP049958:c1261463-1261329 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Toxin

• AlphaFold DB: A0A125V849

Antitoxin